![]() Many studies show that compounds in various parts of sea buckthorn have antioxidant activity 8, 26, 28. ![]() Recently, it has also been shown that sea buckthorn stem extracts have anti-coagulant potential and anti-viral activity 4, 5. Extracts from various parts of this plant show great clinical potential because they are rich in compounds with anti-inflammatory, immunomodulatory, radioprotective and anti-tumor activities 1, 25, 26, 27. It has been suggested that, by acting as antioxidants, quercetin (the most abundant dietary flavonol), kaempferol, morin, myricetin, chlorogenic acid and rutin have anti-inflammatory, antiallergic, antiviral and anticancer effects and protect against liver and cardiovascular diseases 18, 19, 20.Ĭurrently, compounds from sea buckthorn are used for prevention or therapy in cardiovascular, skin, liver and stomach diseases 4, 21, 22, 23, 24. Moreover, flavonoids have been reported not only as powerful antioxidants but also as compounds with multiple biological properties including antimicrobial, cytotoxicity, anti-inflammatory and antitumor activities 16.įlavones and catechins are believed to be the most powerful flavonoids for protecting organisms against ROS 13, 17. These compounds have been considered to be more effective antioxidants than vitamins C and E or carotenoids 15. Flavonoids and phenolics (phenolic acids) are secondary metabolites formed in many plants that have high antioxidant activity and are known to protect cells specifically against the injurious effects of free radicals 14. Many compounds of plant origin have ROS scavenging properties and could therefore be valuable as protective or therapeutic agents in diseases caused by oxidative stress 13. ![]() In the seventh century BCE, this plant was used not only in natural medicine but also in veterinary treatment 8, 9, 10, 11.Įxcess reactive oxygen species (ROS) generation or decreased antioxidant levels in humans cause oxidative stress syndrome, which lead to tissue injury and subsequently lead to pathogenesis of different diseases 12. The healing properties of extracts from different organs of sea buckthorn have long been known. Oils obtained from both the fruit and leaves of sea buckthorn are rich in chemical compounds that show a wide range of biological activities 1, 3, 4, 5, 6, 7. This plant is resistant to salinity, drought and air pollution. It grows mainly in Europe and Asia, preferably in wet places, most often near rivers, as a shrub or low tree 1, 4. Hippophae rhamnoides L., commonly called sea buckthorn, belongs to the Elaeagnaceae family 1, 2, 3. should be considered as a non-toxic source of bioactive compounds which may be of interest to the food, pharmaceutical and cosmetic industries. Our results indicate that leaf and twig extracts of H. Interaction with human serum albumin was investigated and conformational changes were observed. Cytotoxicity and hemotoxicity assays showed that the extracts had low toxicity on human cells over the range of concentrations tested. The results suggest that the studied extracts are rich in bioactive compounds with potent antioxidant properties. Chemical components such as the total content of phenolic compounds, vitamins and amino acids and the antioxidant activities of these compounds in cellular and cell-free systems were assessed. In this study we investigated the chemical composition and biological properties of bioactive components of ethanol extracts from leaves and twigs of H. ![]() is known as a plant with health-promoting properties. Growing demands for these compounds make it important to seek new sources for them. They are also rich in nutrients that improve the human diet. Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents.
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